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Hyun-soon Chong

Hyun-soon Chong, Ph.D.

Hyun-soon Chong, Ph.D.
Professor of Chemistry






398 Robert A. Pritzker Science Center


B.S. Kyung Hee University
Ph.D. University of North Texas

Research & Accomplishments 

My research group is broadly interested in areas of organic synthesis, medicinal chemistry, biochemistry, bioconjugate chemistry, and cell biology. The current work at my laboratory is centered on interdisciplinary research projects aimed at developing safe, effective, and targeted drugs for cancer and neurodegenerative diseases. My lab has developed several promising cancer therapeutic and diagnostic agents with successful preclinical profiles that are favorably compared to the existing cancer drugs. We are also interested in synthetic and mechanistic studies of aziridines and aziridinium ions as reactive intermediate compounds in organic synthesis.


Kang CS, Song HA, Milenic DE, Baidoo KE, Brechbiel MW, Chong HS. “Preclinical evaluation of NETA- based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: radiolabeling,  serum stability, and biodistribution and tumor uptake studies”. Nucl Med Biol. 2013;40(5):600-5.

De Silva RA, Jain S, Lears KA, Chong HS, et al. “Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development”. Nucl Med Biol. 2012;39(8):1099-104.

Kang, CS; Sun, X ;Jia, F; Song, HA ; Chen, YW; Lewis, M; Chong, HS. “Synthesis and Preclinical Evaluation of Bifunctional Ligands for Improved Chelation Chemistry of Y-90 and Lu-177 for Targeted Radioimmunotherapy” BIOCONJUGATE CHEMISTRY. 2012; 23(9) 1775-1782.

Chong HS, Sun X, Dong P, Kang CS. “Convenient Synthesis and Evaluation of Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications”. European J Org Chem. 2011;2011(33):6641-6648.

Dadwal M, Kang CS, Song HA, et al. “Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates”. Bioorg Med Chem Lett. 2011;21(24):7513-5.

Song, HA; Kang, CS; Baidoo, KE; Milenic, DE; Chen, YW; Dai, AZ; Brechbiel, MW; Chong, HS. “Efficient Bifunctional Decadentate Ligand 3p-C-DEPA for Targeted alpha-Radioimmunotherapy Applications”. BIOCONJUGATE CHEMISTRY. 2011

Chong HS, Song HA, Kang CS, et al. “A highly effective bifunctional ligand for radioimmunotherapy  applications”. Chem Commun (Camb). 2011;47(19):5584-6.

Chong HS, Sun X, Dong P, Kang CS. “Convenient Synthesis and Evaluation of Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications”. European J Org Chem. 2011;2011(33):6641-6648.

Chong HS, Song HA, Dadwal M, Sun X, Sin I, Chen Y. Efficient Synthesis of Functionalized Aziridinium Salts. J. Org. Chem. 2010, 75, 219-221.

Chong HS, Song HA, Ma X, Lim SY, Mhaske S, Sun X. Novel bile acid-based polyaminocarboxylates as targeted antitumor agents. Chem. Comm. 2009, 3011–3013.

Chong HS, Song HA, Birch N, Le T, Lim SY, Ma X. Efficient synthesis and evaluation of bimodal ligand NETA. Bioorg. Med. Chem. Lett. 2008, 18, 3436-3439.

Chong HS, Ma X, Le T, Kwamena B, Milenic DE, Song HA, Brady ED, Brechbiel MW. Rational Design and Generation of Bimodal Bifunctional Ligand for Antibody-Targeted Radiation Cancer Therapy. J. Med. Chem. 2008, 51, 118–125.

Chong HS, Ma X, Lee HS, Bui P, Song HA, Birch N. Synthesis and evaluation of novel polyaminocarboxylate-based antitumor agents. J. Med. Chem. 2008, 51, 2208–2215.

Chong HS, Song HA, Lim SY, Macrenaris K, Ma X, Lee HS, Bui P, Meade T. Novel cholic acid-based contrast enhancement agent for targeted MRI. Bioorg. Med. Chem. Lett. 2008, 18, 2505–2508.

Birch N, Wang X, Chong HS. Iron Chelators as Therapeutic Agents. Expert Opinion in Therapeutic Patents (Invited Review). 2006, 16, 1533–1556.