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Ti-Catalyzed Nitrene Transfer Reactions


Jan 31, 2018 - 3:15pm


111 Robert A. Pritzker Science Center Auditorium


Ian A. Tonks
University of Minnesota – Twin Cities


Ti-Catalyzed Nitrene Transfer Reactions: Harnessing the TiII/TiIV Redox Couple for New Organic Methods

Ian A. TonksTitanium is an ideal metal for green and sustainable catalysis—it is the 2nd most earth-abundant transition metal, and the byproducts of Ti reactions (TiO2) are nontoxic. However, a significant challenge of utilizing early transition metals for catalytic redox processes is that they typically do not undergo facile oxidation state changes because of the thermodynamic stability of their high oxidation states. We have recently discovered that Ti imidos (LnTi=NR) can catalyze oxidative nitrene transfer reactions from diazenes via a TiII/TiIV redox couple, and are using this new mode of reactivity to develop a large suite of practical synthetic methods. In this talk, our latest synthetic and mechanistic discoveries related to Ti nitrene transfer catalysis will be discussed, including new synthetic methods for the modular, selective construction of pyrroles via [2+2+1] cycloaddition of alkynes with Ti nitrenes and alkynes, as well as new methods for catalytic oxidative carboamination of other unsaturated organics by Ti nitrenes.

Ian A. Tonks Redox Catalysis

Event Type: 

Department of Chemistry - Colloquia